The sweetner that is a favorite of many food manufacturers in AMerica has been conclusively linked to Type 2 diabetes in at least some capacity. This news is coming out despite the nifty commercials produced by the corn growers depicting the sweetener as safe and desirable.
Part of the press release is here:
“A new study in mice sheds light on the insulin resistance that can come from diets loaded with high-fructose corn syrup, a sweetener found in most sodas and many other processed foods. The report in the March issue of Cell Metabolism, a Cell Press publication, also suggests a way to prevent those ill effects.
The researchers showed that mice on a high-fructose diet were protected from insulin resistance when a gene known as transcriptional coactivator PPARg coactivator-1b (PGC-1b) was “knocked down” in the animals’ liver and fat tissue. PGC-1b coactivates a number of transcription factors that control the activity of other genes, including one responsible for building fat in the liver.
“There has been a remarkable increase in consumption of high-fructose corn syrup,” said Gerald Shulman of Yale University School of Medicine. “Fructose is much more readily metabolized to fat in the liver than glucose is and in the process can lead to nonalcoholic fatty liver disease,” he continued. NAFLD in turn leads to hepatic insulin resistance and type II diabetes.
Metabolic syndrome and type 2 diabetes have both reached epidemic proportions worldwide with the global adoption of the westernized diet along with increased consumption of fructose, stemming from the wide and increasing use of high-fructose corn syrup sweeteners, the researchers noted.
High-fructose corn syrup, which is a mixture of the simple sugars fructose and glucose, came into use in the 1970s and by 2005 the average American was consuming about 60 pounds of it per year. Overall, dietary intake of fructose, which is also a component of table sugar, has increased by an estimated 20 to 40 percent in the last thirty years.
Earlier studies had established that fructose is more readily converted to fatty acids than glucose and had also linked high-fructose diets to high blood levels of triglycerides (a condition known as hypertriglyceridemia), NAFLD and insulin resistance. While researchers had implicated a gene known as SREBP-1, a master regulator of lipids’ manufacture in the liver, much about the underlying molecular connections between fructose and those metabolic disorders remained mysterious.
In the new study, the researchers zeroed in on PGC-1b, a gene known for boosting SREBP-1 levels. To test its role in the effects of fructose, they blocked its activity in mice fed a diet high in that sugar for four weeks.”
So much for the commercials, especially if you are one of the Americans wolfing down the aforementioned 60lbs of high fructose corn sweetener each year.
Until next time…..Lose Your Belly Fat (and the HFC)